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J Neuroendocrinol (2018) 30(3):e12572

Unregulated injections may cause organ damage

However, one may extract some relevant information: among the placebo controlled trials we may retain two [100, 101] that showed significant differences in favor of silymarin in the ALT and AST levels at the end of the trials

Here, we focused primarily on the acute mitochondrial impact of 5FU, and although we arrived at the combination of 5FU and mitochondrial inhibitors (more specifically, 5FU and metformin) somewhat serendipitously, we have now generated evidence to support the use of 5FU and metformin combinations not only in patients with resistant or relapsed disease as previously suggested by others, but also in treatment-naive, first-line chemotherapy settings