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While angiotensin II causes vasoconstriction and salt retention, aldosterone secretion results in salt retention in the short term and tissue fibrosis over the long term, whereas natriuretic peptides counteract these deleterious effects by producing vasodilation and natriuresis [Figure 1.1]

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The signaling networks of insulin receptors entail binding of insulin to the receptor followed by autophosphorylation of the intracellular tyrosine kinase domain of the -subunits and activation of signaling pathways that may be considered in three sequential nodes (30) encompassing the insulin receptor substrate (IRS1/2/3/4), PI3K, and Akt (also known as PKB)