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24,25 However, due to the diversity of its clinical manifestations, the lack of distinct patterns in liver histology, and the complexity of genetic mutations (varying mutation sites, and even the same mutation presenting diverse clinical manifestations), the diagnosis of WD is frequently difficult

94:1313-1319 (2012) Hosaka K, Nikawa J-i, Kodaki T, Yamashita S

From the time it was introduced in 1955, acetaminophen has become one of the most successful OTC drugs, and has earned the primary manufacturer, Johnson & Johnson, an estimated US$1.3 billion every year

sources: 1: Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, Chung YH, Hwang SK, Lee ZW (2005)