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Reviewing the team's patent and related documents at Talpos's request, Anna Mapp, the Edwin Vedejs Collegiate Professor of Chemistry at the University of Michigan, and also the President of the American Peptide Society, questioned the limited detail available and the absence of a published sequence for the peptide's parent protein, an omission she noted makes the original work impossible to reproduce

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4 Immunohistochemistry of interleukin-6 (IL-6) in the dorsal root ganglion (DRG) and spinal cord (SC) at phases (A) 1 and (B) 2 Graph (bottom) represents the number of immunostained cells in the DRG and SC (mean SD)