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Figure 1 Regulatory mechanism (Figure 1): The essence of ferroptosis lies in the depletion of glutathione (GSH) and the decline in the activity of glutathione peroxidase (GPX4), which leads to a reduction in the amount of glutathione reductase catalyzed by GPX4 and excessive accumulation of lipid peroxides (10)

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A post-hoc analysis of the IMbrave150 trial indicates that the biology of hepatocellular carcinoma (HCC) may be influenced by various etiologies, such as viral infections, alcohol-related liver disease, and metabolic conditions like nonalcoholic fatty liver disease (NAFLD)

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