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[DOI] [PMC free article] [PubMed] [Google Scholar] 496.Kootte RS, et al

RT not only induced ROS production, but also induced the expression of ACSL4, a lipid metabolizing enzyme required for ferroptosis, leading to elevated lipid peroxidation and ferroptosis ( + T cells down-regulates the expression of SLC3A2 and SLC7A11, inhibits cystine uptake in cancer cells, and enhances ferroptosis specific lipid peroxidation in tumor cells ( + T cells to inhibit SLC7A11 and increase ferroptosis in tumor cells ( + T cells, induces lipid peroxidation and ferroptosis, and leads to reduced cytotoxic cytokine production and reduced anti-tumor ability ( + T cells from producing IFN- ( Figure 3 )