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Description

Buurman, L.F

The objective of this review is to summarize the current literature on mycotoxin induced nephropathy, particularly in domesticated pigs, focusing on kidney biomarkers monitored by different analytical methods

Biochemical analysis showed an increase in total antioxidant capacity (TAC) and a decrease in malondialdehyde (MDA) and high-sensitivity C-reactive protein (hs-CRP) levels when compared with baseline measurements

However, following administration of the ferroptosis inhibitors liproxstatin-1 or ferrostatin-1, the levels of inflammatory factors and ROS are reduced, endogenous antioxidant pathways related to Nrf2, HO-1, and NQO1 are upregulated, transforming growth factor- expression is downregulated, and iron ptosis is reduced in lung tissue [107]