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Within the intricate gut-kidney axis pathological framework, these therapeutic mechanisms collectively demonstrate rhubarbs multifaceted intervention across four critical junctures: orchestrating intestinal microbiome remodeling through selective bacterial modulation, reinforcing intestinal barrier integrity via colonic epithelial strengthening, optimizing microbial metabolite profiles through uremic toxin reduction and correction of aberrant fermentation processes, and ultimately providing direct renal cellular protection by attenuating both glomerulosclerotic progression and interstitial fibrogenesis

Occup Environ Med 55:393400

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