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Thus, this increase in S-5-HT from before to after L-carnitine was about 8-fold in CFS and 6-fold in hypothyroidism

Increased albumin levels in the brain activate transcriptional signals associated with TGF-, which can maintain inflammation and induce epileptogenesis (93, 144)

Molecular and Cellular Neuroscience, 45 , 192199

This could trigger a positive feedback cycle whereby protein aggregates trigger the aggregation of other proteins in a chain reaction that eventually captures elements of the proteostatic mechanisms in place to counteract them