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Generalized joint hypermobility: joint hypermobility present in many different joints throughout the body Peripheral joint hypermobility: joint hypermobility limited to the hands and feet Localized joint hypermobility: joint hypermobility in a single joint or group of joints in the same area The Beighton Score is a screening tool for generalized joint hypermobility that measures joint hypermobility on a 9-point scale

doi: 10.3389/fendo.2023.1217165 54 HermanJPMcKlveenJMGhosalSKoppBWulsinAMakinsonRet al

Phase II metabolism then further modifies these metabolites, resulting in the formation of conjugated metabolites that are more water-soluble and suitable for excretion

Because methylcobalamin binds more efficiently to transport proteins, it is retained in the liver, kidneys, and nervous system for a significantly longer period