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Abbreviations 51Cr-EDTA: Radioactive chromium complexed with ethylene diamine tetracetic acid AML: Acute myeloid leukemia BG: (1 3)--D-glucan CANs: Circulating aged neutrophils CAR T: Chimeric Antigen Receptor CLE: Confocal laser endomicroscopy CMV: Cytomegalovirus CRC: Colorectal cancer CRS: Cytokine release syndrome DAMPs: Damage-associated-molecular patterns ESBL: Extended-spectrum beta-lactamases EndoCAb: Endotoxin core antibodies FITC: Fluorescein isothiocyanate FMT: Fecal microbiota transplant GI: Gastrointestinal GVHD: Graft-versus-host disease HIV: Human immunodeficiency virus HbS: Sickle hemoglobin IBD: Inflammatory bowel diseases iFABP: Intestinal fatty acid binding protein IFN: Interferon IL: Interleukin IgA: Immunoglobulin A KGFs: Keratinocyte growth factors L:M: Lactulose:mannitol LBP: Lipopolysaccharide binding protein LPS: Lipopolysaccharide MACs: Microbiota-accessible carbohydrates MAPK: Mitogen-activated protein kinase MDS: Myelodysplastic syndrome MHC: Major-histocompatibility complex MLCK: Myosin light chain kinase MTX: Methotrexate MUC 2: Mucin 2 MYD88: Myeloid differentiation factor 88 NF-B: Nuclear factor kappa B PAMPs: Pathogen-associated-molecular patterns PEG: Polyethylene glycol PMP: Pre-leukemic myeloproliferation PRRs: Pattern recognition receptors SCD: Sickle cell disease SCFAs: Short-chain fatty acids TJs: Tight junctions TLRs: Toll-like receptors TNF: Tumor necrosis factor VOC: Vaso-occlusive crisis References Michielan A, DInc R

Free radicals are molecules that contain an unpaired electron, which can cause damage to cells in the body, which can lead to accelerated aging, and degenerative diseases such as cancer over time

Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration