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To bypass this impenetrable barrier, the cell relies entirely on a three-step biochemical pathway known in medical literature as the carnitine shuttle

10.1016/j.cbi.2021.109368 8 AragonaM.PancieraT.ManfrinA.GiulittiS.MichielinF.ElvassoreN.et al (2013)

Ultrasound gel was applied to the depilated skin of the abdomen, and imaging was performed with a Vevo3100 imaging system (VisualSonics)

the anti-ALPP/ALPPL2 antibodies described herein can be coupled directly to the radio-opaque moiety (e.g., at an available cysteine) or they can be attached to a "package" (e.g., a chelate, a liposome, a polymer microbead, a nanoparticle, etc.) carrying, containing, or comprising the radio-opaque material, e.g., as described below