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In addition, Cu + in the cytoplasm can be transported to the mitochondrial intermembrane space, in which Cu + binds to chaperone cytochrome oxidase 17 (COX17) and is delivered to either the chaperone synthesis of cytochrome oxidase 1 (SCO1) or COX11, ultimately delivering to the cytochrome C oxidase (CCO) I (COX1) or II (COX2) subunits to involve them in the respiratory chain (Horng et al., 2004)

Vitamin C or its breakdown products react with their substrate proteins to accelerate cataract development

Metallothioneins may be involved in counteracting the pro-oncogenic effects of PFAS in the liver

We confirm that co-treatment with 5FU and mitochondrial inhibitors, particularly CI inhibitors IACS-010759 (a specific CI inhibitor under clinical evaluation 51 ) and metformin hydrochloride (a treatment for diabetes that inhibits CI 52 ), increases growth arrest and death in CRC cells (Fig