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[1] [6] Severe deficiencies may include symptoms of reduced heart function, suppression of bone marrow, as well as more various severe neurological symptoms possibly including sensory loss, abnormal balance and reflexes, memory and consciousness impairment, smell and taste problems, depression, irritability, confusion, and psychosis

Moreover, recent studies have revealed the oxidative sensitivities of purified mammalian methionine synthase and CBS, suggesting a redox regulation of the remethylation and transsulfuration pathway

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