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Mcl-1 and Bcl-xL are essential for survival of the developing nervous system

While it is possible to feel a slight pricking sensation, the injections are made with a small amount of lidocaine to minimize discomfort

The lumbar spine (lower back) consists of five vertebrae labeled L1 through L5

This interpretation is also consistent with the clinical efficacy of liver transplantation, where replacement of the main site of TTR production reduces disease progression despite continued peripheral tissue expression of TTR