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Moreover, mRNA and miRNA library sequencing studies have indicated that EGCG specifically modifies mRNA and miRNA expression, leading to cell death in lung cancer and breast cancer (MCF-7) cells [598, 599]

At the same time, it can inhibit key inflammatory and apoptotic signaling pathways such as JNK/c-Jun, and regulate the expression of fibrotic factors such as TGF-

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received honoraria from Janssen, Probi, Ingelheim Boehringer and Apsen, as an invited speaker, and research funding from Pharmavite, Reckitt, Tate & Lyle PLC, Nestle, Fonterra and is or has been a paid consultant for Heel Pharmaceuticals, Bayer Healthcare, Yakult and Zentiva