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These include inflammation, energy failure, loss of cellular homeostasis, acidosis, elevated intracellular calcium levels, excitotoxicity, cytokine- and free radical-mediated cytotoxicity, complement system activation, disruption of the blood-brain barrier, activation of glial cells, oxidative stress, and leukocyte infiltration (Figure 1) ( FIGURE 1 3.1 Oxidative stress Oxidative stress occurs when the production of reactive oxygen species (ROS) exceeds the bodys ability to neutralize and eliminate them ( Reactive nitrogen species (RNS) are highly reactive molecules produced during nitrogen metabolism

Wiederhold et al., 2010

Therefore, calpain-mediated Hsp70.1 cleavage was studied in vitro , by comparing normal and oxidized tissues of the monkey hippocampal CA1 (Figure 6

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