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Methods: This was a retrospective cohort study conducted using the TriNetX database and the US Collaborative Network, which includes healthcare information records from 60 healthcare organizations

Sheppe, A

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First of all, cancer cells, unlike healthy eukaryotic cells that contain zwitterionic phosphatidylcholine and sphingomyelin in their membranes and therefore overall neutrally charged, 91 carry a net negative charge due to the elevated expression of anionic molecules such as phosphatidylserine (PS) and O-glycosylated mucins in their outer membrane leaflet, 92,93 which results in a greatly enhanced capacity for electrostatic interactions with AMPs