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Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease

doi: 10.3390/antiox9060523 57 SongYLiXLiYLiNShiXDingHet al

10.3390/molecules28166118 71 LienhardG

Chemonucleolysis is a form of non-surgical treatment for discogenic pain and herniated discs (Alexander, 1986), which involves the administration of a proteolytic enzyme like chymopapain into the IVD to alleviate fibrotic tissue damage and reduce disc bulging (Thomas, 1956)