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Ethics declarations Conflict of interest The authors declare that they have no conflict of interest

GHK-Cus gene expression effects modulating an estimated 4,000+ genes in published research by Pickart and Margolina operate at the cellular level throughout distributed tissues when administered systemically

The 12-week mark aligns with what clinical GHK-Cu skin trials use as their primary endpoint, and the published results from those trials reflect what researchers running systematic protocols report: clear, documented improvement in skin architecture

It can also regulate specific gene expression, cellular secretion, and membrane permeability