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592,593 Moreover, due to the decrease of 3-hydroxykynurenine (a cytotoxic metabolite of KMO), the mice that lack active kynurenine 3-monooxygenase (KMO) will not develop into AKI after I/R injury

doi: 10.1038/nrdp.2017.40 70 RogersEJChenSChanA

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Furthermore, short-term high-dose use for correcting a deficiency is medically standard and safe, while the implications of indefinite, high-dose supplementation in individuals with already normal levels are less studied and form the basis of most consumer questions