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In general, alcohol-containing beverages that are darker in color (e.g., bourbon, red wine) typically have higher congener levels than those lighter in color (e.g., vodka, white wine) and are linked to triggering more pronounced hangover symptoms with more severe headaches (43, 44)

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5,10-Methylene tetrahydrofolate (THF) is required for the synthesis of nucleic acids and is reduced to 5-methyl THF by methylene THF reductase, a flavin-dependent enzyme that uses NADPH as a cofactor