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Kim HO, Yeom M, Kim J, Kukreja A, Na W, Choi J, Kang A, Yun D, Lim JW, Song D, et al

Prolonged exposure to ozone may adversely affect the respiratory system, fostering the release of deleterious compounds into the bloodstream and potentially resulting in multiorgan damage [81]

It could be shown that glycolysis in ECs is mainly regulated by PFKFB3 ( in vivo in an EC-specific Pfkfb3 -deficient mouse model, demonstrating that the lack of Pfkfb3 results in decreased branch points and sprouts in a postnatal retina model ( 6.1.2 Pentose phosphate pathway Besides the use of glucose as energy source, it can also be phosphorylated by hexokinase 2 to generate glucose-6-phosphate, which subsequently can be stored as glycogen or further processed in the PPP to yield NADPH (Mann et al., 2003