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The over-abundance of ROS decreases collagen synthesis and increases collagen breakdown by stimulating matrix metalloproteinase (MMP) expression, eventually causing the alterations of the dermal matrix 5, 6
Fu Z, Du H, Meng S, Yao M,Zhao P, Li XZX, Yuan Z,Yang H, Cai K, Dai L
Pre-clinical trials have shown favorable toxicity results, and it is considered to be safe by most researchers
