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Animal procedures were performed in accordance with the Ethics Committee of the National Research Centre and followed the recommendations of the National Institutes of Health Guide for Care and Use of Laboratory Animals (Publication No

GPR109A, also known as hydroxy-carboxylic acid receptor 2 (HCA2), is a G protein-coupled receptor that is located on neutrophils, macrophages, adipocytes

2 Materials and methods To achieve the objective of this review, relevant reference from the last 25 years have been obtained from the databases including PubMed, Science Direct, MEDLINE, Springer Nature, SciFinder, Scopus, Excerpta Medica dataBASE (EMBASE), Web of Science, National Center for Biotechnology Information (NCBI), and Google Scholar databases

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