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Hyperinsulinemia and hyperglycemia may enhance the production of free radicals and induce oxidative stress that may also contribute to increased risk for coronary artery disease in diabetes [4]

Combined treatment of pancreatic cancer cells with gemcitabine and -MT significantly inhibited proliferation and migration 110

ROS-induced apoptosis also explains the beneficial effect of two analogs of nuclear receptor ligands in several types of cancer: 2-methoxyestradiol, a 17-estradiol metabolite, and N-(4-hydroxyphenyl) retinamide, a synthetic analog of retinoic acid, have been shown to induce PCD in neuroblastoma and lung cancer cells, respectively 104,105

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