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This promotes local PI3P synthesis and provides a platform for recruiting autophagy precursor proteins, such as DFCP1 and WIPI1, thereby initiating isolation membrane nucleation and elongation [95]

Such studies have either only characterized the metabolism of untreated resistant cells compared to sensitive cells [12, 15, 17], or also considered the effects of exposure to cDDP [13, 14], oxaliplatin [13, 16] or carboplatin [13] on both cell lines (sensitive and resistant)