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Naproxen is an NSAID like ibuprofen, so similar considerations apply

Neuroimmunomodulation 17, 405410

Decreased serum calcium stimulates parathyroid hormone secretion, leading to increased osteoclast activity, which in turn exacerbates bone destruction (59)

Transient human MC4R transfected HEK293T cells were pelleted, washed and resuspended in stimulation buffer (LANCE Ultra cAMP assay) supplemented with 0.1% BSA according to the manufacturers instructions