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Future studies should delve into the potential long-term advantages and safety aspects of selenium and myo-inositol supplementation

Author contributions MG-E: Writing review and editing, Formal Analysis, Writing original draft, Investigation, Conceptualization

Crucial Safety Reminder Never shorten the treatment: If your dog seems to be recovered, do not stop the treatment plan as prescribed by your veterinarian, otherwise your dog may return to normal

Increased NRF2 expression and catalase activity at 40C were inhibited by the antioxidant PEG-catalase and the p53 inhibitor pifithrin-, suggesting that mild thermotolerance (40C) increases prooxidant levels, which in turn activates NRF2 (Glory and Averill-Bates, 2016)