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Utilizing a network pharmacology approach enables a systematic study of potential target proteins and pathways of drugs at the molecular level, allowing us a closer look at potential therapeutic targets

Intriguingly, TLR2 signaling may, in specific contexts, exert protective effects by inducing anti-inflammatory factors like IL-10[58], suggesting context-dependent functionalities among TLR family members

For instance, in progenitors, we observed a shift to the left in the PC1 axis by ageing, which was shifted back to the right by MetR (Supplementary Fig

The wide range of CP dosages used in models, some exceeding clinically relevant exposures, further complicates relevance to patient care