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Eur J Pain 2002;6:2534.ArticlePubMed 22

Redox Biol 2013, 1:508513

GPX4 activity is dependent on Glutathione (GSH) which is synthesized using cystine imported via the cystine-glutamate antiporter, System Xc

These variations may result from changes in altitude, diseases that impair blood oxygenation, or defects in glycolytic enzymes, and they affect hemoglobin binding affinity for oxygen