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Markedly, 4-HNE has been shown to affect mitochondria by impairing ATPase activity, disrupting oxygen consumption, and even triggering premature apoptosis via adduct formation with c-Jun NH 2 -terminal kinase (JNK) (13) (Fig

The RANK-TRAF6 structure was preferred over the CD40-TRAF6 structure PDB 1LB6 46 as the template for modelling, because our functional studies suggested that LMP1-TRAF6 is more closely related to RANK-TRAF6 than to CD40-TRAF6

The major organs of elimination for Phase II metabolism are usually liver, kidney and intestine, though there may be important tissue specific metabolism