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Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur

In this study, we demonstrate that AML cell death occurring early after APR-246 exposure is suppressed by iron chelators, lipophilic antioxidants and inhibitors of lipid peroxidation, and correlates with the accumulation of markers of lipid peroxidation, thus fulfilling the definition of ferroptosis, a recently described cell death process

Charvet C, Wissler M, Brauns-Schubert P, Wang S-J, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U (2011) Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53

Vitamin B12 is necessary only in very small amounts each day