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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

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Standardization of measurement techniques, reporting of important patient characteristics such as disease severity, onset, and duration, as well as concomitant illnesses and medications, and additional studies in MCI would allow for better characterization of early biomarkers changes in different stages of cognitive impairment