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Also, glutamate excitotoxicity NMDA-mediated intra-neuronal calcium overload elevates NO synthesis contributing to oxidative stress particularly the production of reactive nitrogen species which are able to cause defects in DNA and protein phosphorylation pathway (85)

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Therapeutic strategies aimed at reinforcing antioxidant pathways (such as GPX4, CoQ10, and BH4) may offer promising avenues to mitigate ferroptosis-related neurodegeneration