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Abstract Ferroptosis, a newly identified, iron-dependent type of programmed cell death, is active in several diseases, such as heart disease, brain damage, and cancer

Oxidative stress contributes to metastasis by influencing multiple steps of the metastatic cascade, including epithelial-mesenchymal transition (EMT), invasion, intravasation, survival in the circulation, extravasation, and colonization of distant organs [118]

Pathophysiology of CHE Central role of ammonia in CHE CHE pathophysiology is centered on impaired liver functional reserve and neurocognitive dysfunction arising from brain alterations, but also involves complex multi-organ interactions, in which hyperammonemia, inflammation, sarcopenia, and the gutliver axis play critical roles ( Fig