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Preparation of Figures: TT, JMB

Interestingly, acetyl-CoA can synergize with GSH to exert an anti-ferroptosis effect [43], while the production of taurine reduces intracellular GSH levels and increases ROS production [44]

Notably, these biochemical improvements were accompanied by amelioration of cognitive and behavioral deficits, suggesting that ferroptosis is not only pathogenic but also potentially reversible and targetable (Li J

The results of clinical studies should be reflectively considered in determining the reasons for the failure of the clinical investigations of NAMI-A and KP1019, which could lead to design drugs with less side effects, greater selectivity, and higher bioavailability