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Supplementary information This file contains Supplementary Figs

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Estrogen deficiency and the decline of skin collagen were first observed in 1941 by Albright, who noticed that thin skin was more common in older women with osteoporotic fractures [21]

Additionally, the COMPARE algorithm was used to evaluate the similarity of the biological response pattern of ZOT 5 -1-Me and ZOT 5 -1-Et with both FDA-approved drugs and chemotherapeutics undergoing combination clinical trials for GBM (Fig