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Qu et al., 2021

2 Materials and methods 2.1 Genome-wide association study data acquisition We obtained the GWAS dataset for 5-oxoproline levels (ebi-a-GCST90200280) from the GWAS Catalog, originating from the Canadian Longitudinal Study on Aging (CLSA) ( 2.2 Instrumental variables selection We employed a multi-step filtering approach to identify valid instrumental variables for genetic causal analysis

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The next critical step in this research involves conducting in vivo studies to confirm neuroprotective activity, for example, using established mouse models