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Description

A rejection, delay, label limitation, or additional trial requirement would also matter

Non-cleavable linkers (e.g., SMCC), characterized by high stability in plasma, can only undergo degradation in the lysosome to release the payload

Methods Cell lines and culture conditions HEK293T, U-2 OS, NCI-H460, NCI-H441 and NCI-H1703 cells were obtained from the University of California, Berkeley (UC Berkeley) Cell Culture Facility