methionine restriction glutathione

methionine restriction glutathione and Cancer Biology Dietary methionine restriction in cancer

Name: methionine restriction glutathione and Cancer Biology Dietary methionine restriction in cancer
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Dietary methionine restriction in cancer development and antitumor immunity: Trends in Endocrinology & Metabolism Early adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila Nature Communications Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts Gut Frontiers Methionine restriction in cancer: a dietary insight for therapy

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USA , 99 , 15932-15936, Burk, R

Although xCT expression is confined to the plasma membrane in normal tissues (36,39), it is upregulated in certain types of cancer, such as colorectal cancer, malignant glioma and non-small cell lung cancer, which increases cystine uptake (4042)

It was shown that this type of modification can form dimers of Kelch-like ECH-associated protein 1 (KEAP1) proteins, which in turn can activate nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor, and thereby promote the transcription of antioxidant genes [44]