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To further interrogate the underlying dynamics of the Cagri-AMY 3 R complex, relative to rAmy-AMY 3 R complex, we performed molecular dynamics (MD) simulations of Cagri:AMY 3 R:G s and rAmy:AMY 3 R:G s (each system in triplicate, for a total of 6 s)

Cardiac-specific deletion of MED13 increases susceptibility to obesity, whereas its overexpression promotes a lean phenotype

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Furthermore, while Tozasertib demonstrated strong efficacy at modest doses, its previously reported cardiotoxicity, myelosuppression, and limited data on brain penetrance warrant cautious interpretation of its translational potential 83