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The relationships between microglia and other cells, such as astrocytes and neurons, further extend the scope of inflammation, forming a complex network of inflammatory regulation

Sima AAF, Calvani M, Mehra M, et al

A.BrownK.RamayH.et al (2020)

This seems counterintuitive since tirzepatide activates an additional receptor, but the GIP component appears to have a moderating effect on GLP-1 induced nausea