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As many as 5% of patients who end up being diagnosed with vitamin B12 deficiency have blood B12 concentrations above a commonly used cut-off of about 150 mol/L, and even more have abnormal methylmalonic acid (MMA) or homocysteine levels, which are signs of functional B12 deficiency even if overt symptoms are not apparent

Treatment protocols typically recommend 2-3 sessions weekly over a 4-8 week period

Huang, R., Hong, Y., Wu, Y., Li, W

NICE NG28 (Type 2 Diabetes in Adults: Management) and associated NICE pathways highlight that HbA1c results should be interpreted in the context of the patient's full clinical picture