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In contrast, tau pathology has emerged as a more promising target for therapeutic intervention, as its accumulation is more strongly correlated with disease progression (r 0.60.8)

IL-1 and IL-6 primarily derived from microglia are important mediators of cerebellar neuron activity ( Figure 2 )

Active compound: Nicotinamide n-methyltransferase

However, natural glutathione synthesis in these cells relies on the recycling of its constituents, and as a consequence, the increase in glutathione circulating in the blood can still support this process