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M72/AS01E has shown significant efficacy in preventing active TB disease in adults with latent Mtb infection, eliciting robust antigen-specific Th1 immune responses characterized by IFN- production (Scriba et al., 2020)

Dock-Bregeon et al

In this context, elevated levels of proinflammatory cytokines, such as IL-1 and TNF-, drive excessive activation of both peripheral and central immune systems