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In this longitudinal study, they determined that at baseline the expression of Nrf2 and Nrf2-related genes (heme oxygenase (HO)-1 and glutamate-cysteine ligase catalytic (GCLC) subunit) in PBMCS was significantly increased in COPD compared to no-COPD subjects, whereas at the follow-up (49.7 6.9 months) the expression was significantly decreased in COPD which worsened over that time, while no changes were observed in no-COPD subjects

380 For example, the PADs (Section 4), microarrays, or chemical noses (Section 5) within a single test strip is an example of spatial multiplexing, where combinational colors encode different analytes in multiple detection spots, addressing the need for comprehensive diagnostic testing