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Chronic abuse is associated with cognitive impairments, including memory and attention deficits, psychotic-like symptoms (hallucinations and delusions), and motor dysfunction (Morgan et al., 2004)

Metabolome statistical analysis For analysis, the raw metabolome data was rescaled to set the median of all metabolites equal to 1, the missing values were imputed with the minimum, and each value was transformed using the natural log

The obtained data were subtracted from the background values, and non-linear regression analysis was performed using Graphpad Prism software to calculate the IC 50 of the curve, thereby determining the affinity of the nanobody

In rat studies, BPC-157 improved healing across multiple musculoskeletal tissues