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Figure 6A demonstrates that there was no detectable fluorescence signal at the tumor site 24 h after the intravenous administration of free RhB, suggesting that free RhB did not accumulate specifically at the tumor site

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New delivery mechanisms, such as microneedle patches, sustained release implants, and targeted liposomal carriers, are being developed to enhance tissue targeting and minimize dosing frequency

Binding to the miR-93 HG promoter was observed only in protein extracts from cells stably expressing CREB1 but not with extracts from cells stably expressing CRTC2, and specificity was confirmed by the reduced binding in the presence of competitive probes (Fig