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Cocaine self-administration alters transcriptome-wide responses in the brains reward circuitry

The Panel used the IC/BPS definition agreed upon by the Society for Urodynamics and Female Urology (SUFU): "An unpleasant sensation (pain, pressure, discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms of more than six weeks duration, in the absence of infection or other identifiable causes. 2 This definition was selected because it allows treatment to begin after a relatively short symptomatic period, preventing treatment withholding that could occur with definitions that require longer symptom durations (i.e., six months)

PMC6840693

These studies are mechanistically aligned with the VEGFR2/eNOS in vitro findings but rely on the same originating laboratory and rodent model system, and independent replication outside that network is sparse